Scientific Visualization & Communication

Intracellular function of complement C3 in bacterial autophagy

  • Client: Prof. Michael Corrin
    Dr. Stephen Girardin (Content Advisor)
  • Medium: Adobe Illustrator
  • Created: Dec 15, 2016
An editorial piece depicting recent research by Dr. Stephen Girardin. The process of bacterial autophagy requires many components being recruited to initiate and encourage phagophore formation and so the challenge was how to visually depict the complicated process in a dynamic but clear way. The focus of the project was on storytelling and layout. The process was organized into steps to allow for the reader to easily digest the information and I decided to utilize a curved path to allow a good reading flow.

Editorial, two-page spread

Preliminary, 2D figure to accompany the article in a journal

Work progress

Works Referenced

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Maekawa, Sakiko, Umeharu Ohto, Takuma Shibata, KensukeMiyake, and Toshiyuki Shimizu. 2016. Crystal Structure of NOD2 and ItsImplications in Human Disease. Nature Communications 7 (May). NaturePublishing Group. doi:10.1038/ncomms11813.

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Nakagome, Shigeki, Shuhei Mano, Lukasz Kozlowski, Janusz M.Bujnicki, Hiroki Shibata, Yasuaki Fukumaki, Judith R. Kidd, Kenneth K. Kidd,Shoji Kawamura, and Hiroki Oota. 2012. CrohnÕs Disease Risk Alleles on theNOD2 Locus Have Been Maintained by Natural Selection on Standing Variation. MolecularBiology and Evolution 29 (6): 1569Ð85. doi:10.1093/molbev/mss006.

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Randow, Felix, and Richard J. Youle. 2014. Self and Nonself:How Autophagy Targets Mitochondria and Bacteria. Cell Host and Microbe15 (4): 403Ð411. doi:10.1016/j.chom.2014.03.012.

Royet, Julien, and Roman Dziarski. 2007. PeptidoglycanRecognition Proteins: Pleiotropic Sensors and Effectors of AntimicrobialDefences. Nature Reviews. Microbiology 5 (4): 264Ð77.doi:10.1038/nrmicro1620.

Shan, Yibing, Michael P Eastwood, Xuewu Zhang, Eric T Kim,Anton Arkhipov, Ron O Dror, John Jumper, John Kuriyan, and David E Shaw. 2012.Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase andPromote Receptor Dimerization. Cell 149 (4). Elsevier Inc.: 860Ð70.doi:10.1016/j.cell.2012.02.063.

Sorbara, Matthew T., and Stephen E. Girardin. 2015. EmergingThemes in Bacterial Autophagy. Current Opinion in Microbiology 23:163Ð70. doi:10.1016/j.mib.2014.11.020.

Tattoli, Ivan, Matthew T. Sorbara, Dana J. Philpott, andStephen E. Girardin. 2012. Bacterial Autophagy: The Trigger, the Target andthe Timing. Autophagy 8 (12): 1848Ð50. doi:10.4161/auto.21863.

Travassos, Leonardo H, Leticia A M Carneiro, MahendrasinghRamjeet, Seamus Hussey, Yun-Gi Kim, Jo‹o G Kim, Linda Yuan, et al. 2010. Nod1and Nod2 Direct Autophagy by Recruiting ATG16L1 to the Plasma Membrane at theSite of Bacterial Entry. Nature Immunology 11 (1): 55Ð62.

Walczak, Marta, and Sascha Martens. 2013. Dissecting theRole of the Atg12-Atg5-Atg16 Complex during Autophagosome Formation. Autophagy9 (3): 424Ð25. doi:10.4161/auto.22931.

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